Asthma Genetics
New findings reported from University of Cincinnati, Division of Immunology describe advances in asthma genetics
Published in Genetics and Environmental Health Week, January 17th, 2007
Scientists discuss in "Diisocyanate asthma and gene-environment interactions with IL4RA, CD-14, and IL-13 genes" new findings in asthma. "Diisocyanate asthma (DA) affects 2% to 10% of exposed workers, yet the pathogenetic mechanisms underlying this disorder remain ill defined. To determine if specific single nucleotide polymorphisms (SNPs) of interleukin 4 receptor alpha (IL4RA), IL-13, and CD14 promoter genes are associated with DA," researchers in the United States report.
"Sixty-two workers with DA confirmed by specific inhalation challenge (SIC) and 75 diisocyanate-exposed, SIC-negative workers were analyzed for SNPs associated with IL4RA, IL-13, and CD14 promoter...
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