Squamous Cell Carcinoma Genetics
Scientists at University of Pennsylvania, Department of Medicine target squamous cell carcinoma genetics
Published in Genetics and Environmental Health Week, January 17th, 2007
Data detailed in "Tumorigenic conversion of primary human esophageal epithelial cells using oncogene combinations in the absence of exogenous Ras" have been presented. In this recently published study, investigators in the United States conducted a study "To investigate pathways of human esophageal squamous cell transformation, we generated esophageal tumor cells using human telomerase-and SV40-immortalized primary esophageal epithelial cells (EPC2) by overexpression of selected combinations of oncogenes. H-Ras, c-Myc, or Akt, but not epidermal growth factor receptor (EGFR), induced transformed colonies in soft agar."
"By contrast, bioluminescence imaging of genetically...
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