Alzheimer Disease

Study results from University of Maastricht update understanding of Alzheimer disease

Published in Genetics and Environmental Health Week, June 25th, 2008

According to recent research from Netherlands, "Accumulation of proteins in inclusions in neurological disorders is partly due to dysfunction of the ubiquitin-proteasome system. Proteasomal dysfunction may be caused by misexpression of one or more of its subunits."

"A large number of antibodies reactive with proteasome subunits were screened on material from patients exhibiting tau- and synucleinopathies. Many antisera against proteasomal subunits (11S activator, 19S regulator ATPase/non-ATPase, and 20S alpha and beta resulted in a distinct nuclear and/or cytoplasmic staining of the entorhinal hippocampal area and the temporal cortex of Alzheimer's disease (AD)...

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Source: Genetics and Environmental Health Week (2008-06-25)

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