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Ovarian Cancer

Research findings from D. Bernardgallon et al update understanding of ovarian cancer

Published in Genetics and Environmental Health Week, August 20th, 2008

"Breast and ovarian cancers increased in the last decades. Except rare cases with a genetic predisposition and high penetrance, these pathologies are viewed as a polygenic disease," scientists in Clermont-Ferrand, France report.

"In this concept, association studies look for genetic variations such as polymorphisms in low penetrance genes, i.e. genes in interaction with environmental factors. DNA repair systems that protect the genome from deleterious endogenous and exogenous damages have been shown to have significantly reduced. In particular, enzymes of the nucleotide excision repair pathway are suspected to be implicated in cancer. In this study, 2 functional...

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