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Parkinson Disease

New findings from Uniformed Services University of the Health Sciences in the area of Parkinson disease published

Published in Genetics and Environmental Health Week, August 20th, 2008

"Microtubule-associated protein tau ( MAPT) has been associated with several neurode-generative disorders including forms of parkinsonism and Parkinson disease (PD). We evaluated the association of the MAPT region with PD in a large cohort of familial PD cases recruited by the GenePD Study," investigators in the United States report.

"In addition, postmortem brain samples from patients with PD and neurologically normal controls were used to evaluate whether the expression of the 3-repeat and 4-repeat isoforms of MAPT, and neighboring genes Saitohin (STH) and KIAA1267, are altered in PD cerebellum. Twenty-one single-nucleotide polymorphisms ( SNPs) in the region of MAPT...

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