Breast Cancer

Studies from National Institutes of Health reveal new findings on breast cancer

Published in Genetics and Environmental Health Week, August 20th, 2008

According to a study from the United States, "Membrane-type I matrix metalloproteinase (MT1-MMP) is associated with multiple forms of cancer including mammary cancer. To directly evaluate the significance of MT1-MMP expression in tumor progression and metastasis using a genetically induced cancer model, we crossed MT1-MMP-deficient mice to MMTV-polyoma virus middle T-antigen (PyMT) mice."

"Expression of PyMT in the MT1-MMP-deficient background consistently resulted in hyperplasia of the mammary gland as seen in wild-type PyMT littermates. Following orthotopic transplantation of PyMT + glands into the cleared mammary fat pad of syngeneic recipient mice, MT1-MMP-deficient...

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Source: Genetics and Environmental Health Week (2008-08-20)

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