Published in Genetics and Environmental Health Week, August 20th, 2008
"We explored systematic annotation by using homologous recombination to modify a native gene in hemizygous (wt/Delta exon) human cancer cells, generating a novel syngeneic variance library (SyVaL). We created a SyVaL of BRCA2 variants: nondeleterious, proposed deleterious, deleterious, and of uncertain significance. We found that the null states BRCA2(Delta ex11/Delta ex11) and BRCA2(Delta...
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