Cystic Fibrosis
Findings in cystic fibrosis reported from University of Colorado
Published in Genetics and Environmental Health Week, August 20th, 2008
According to recent research published in the American Journal of Respiratory Cell and Molecular Biology, "This is the first report to describe a role for Lung Kruppel-like Factor (LKLF or KLF2) in inflammatory airways diseases. In the present study, we identify that LKLF is constitutively expressed in the small airways of normal lungs; however, its expression disappears in severe airway diseases, such as cystic fibrosis (CF) and chronic obstructive pulmonary disease."
"LKLF from primary airway epithelial cells inhibits NF-kappa B-driven transcription induced by Pseudomonas aeruginosa 7-fold, but is down-regulated in the presence of TNF-alpha and activated human...
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