Published in Genetics and Environmental Health Week, June 3rd, 2009
"Tertiary referral center. One hundred four Dutch patients with an adult-onset, sporadic upper motor neuron syndrome of at least 3 years' duration. Hereditary spastic paraparesis was genetically confirmed in 14 patients (7 with SPG4 and 7 with SPG7 mutations). All 14 patients with the SPG4 or SPG7 mutation had symptom onset in the...
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