Small Intestine

Research from Ohio State University, Medical Department has provided new data on small intestine

Published in Genetics and Environmental Health Week, June 3rd, 2009

According to recent research from the United States, "Actions of lubiprostone, a selective type-2 chloride channel activator, on mucosal secretion were investigated in guinea pig small intestine and colon. Flat-sheet preparations were mounted in Ussing flux chambers for recording short-circuit current (I-sc) as a marker for electrogenic chloride secretion."

"Lubiprostone, applied to the small intestinal mucosa in eight concentrations ranging from 1-3000 nM, evoked increases in I-sc in a concentration-dependent manner with an EC50 of 42.5 nM. Lubiprostone applied to the mucosa of the colon in eight concentrations ranging from 1-3000 nM evoked increases in I-sc in a...

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Source: Genetics and Environmental Health Week (2009-06-03)

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