DNA Research
Reports summarize DNA research study results from A.G. Mahabir and co-researchers
Published in Genetics and Environmental Health Week, September 2nd, 2009
"The clastogenic effects of MMC and BLM and the mutagenic effects of B[a]P, N-ac-AAF and ENU were studied in mouse embryonic fibroblasts derived from wild-type (WT) and Rad54/Rad54B-deficient mice. Clastogens as well as mutagens showed a statistically significant induction of mutations in the lacZ reporter gene both in a WT and Rad54/Rad54B-deficient genetic background," scientists writing in the journal Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis report.
"Rad54/Rad54B MEFs appeared equally sensitive to the clastogens compared to WT MEFs, except for MMC. The type of mutations induced by the different compounds was investigated further...
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