Enzyme Research
Data on enzyme research described by researchers at National Institutes of Health
Published in Genetics and Environmental Health Week, February 3rd, 2010
Research findings, 'Deletion of Ogg1 DNA glycosylase results in telomere base damage and length alteration in yeast,' are discussed in a new report. "Telomeres consist of short guanine-rich repeats. Guanine can be oxidized to 8-oxo-7,8-dihydroguanine (8-oxoG) and 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyG). 8-oxoguanine DNA glycosylase (Ogg1) repairs these oxidative guanine lesions through the base excision repair (BER) pathway," researchers in the United States report.
"Here we show that in Saccharomyces cerevisiae ablation of Ogg1p leads to an increase in oxidized guanine level in telomeric DNA. The ogg1 deletion (ogg1Delta) strain shows telomere...
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