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Scientists at University of Ulster, Biomedical Sciences Research Institute publish research in life sciences

Published in Genetics and Environmental Health Week, February 17th, 2010

New research, 'Cytochrome P450 1B1 mRNA untranslated regions interact to inhibit protein translation,' is the subject of a report. "CYP1B1 mRNA is expressed constitutively in all normal extrahepatic human tissues, though the protein is usually undetectable. In contrast, CYP1B1 protein is expressed at high levels in tumors," researchers in Coleraine, the United Kingdom report.

"In this study CYP1B1 mRNA and protein expression was measured in a panel of cell lines indicating that CYP1B1 regulation is altered in tumor cell lines in vitro. Interrogation of ONCOMINE revealed that CYP1B1 mRNA is not significantly overexpressed in tumors compared to normal tissues, suggesting...

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