Breast Cancer

Research on breast cancer discussed by scientists at Oulu University

Published in Genetics and Environmental Health Week, March 10th, 2010

According to a study from Oulu, Finland, "About 5-10% of breast cancer is due to inherited disease predisposition. Many previously identified susceptibility factors are involved in the maintenance of genomic integrity."

"AATF plays an important role in the regulation of gene transcription and cell proliferation. It induces apoptosis by associating with p53. The checkpoint kinases ATM/ATR and CHEK2 interact with and phosphorylate AATF, enhancing its accumulation and stability. Based on its biological function, and direct interaction with several known breast cancer risk factors, AATF is a good candidate gene for being involved in heritable cancer susceptibility. Here we...

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Source: Genetics and Environmental Health Week (2010-03-10)

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