Memorial Sloan-Kettering Cancer Center
A mutant fusion gene protects hematopoietic stem cells from chemotherapy
Published in Genetics and Environmental Law Weekly, February 19th, 2005
According to a study from the United States, "myelosuppression is one of the major side effects of most anticancer drugs. To confer myeloprotection, our laboratory generated drug-resistant mutants of select target human enzymes for gene transfer to the bone marrow."
"Mutants of two of these enzymes, dihydrofolate reductase (DHFR F/S) and thymidylate synthase (TS G52S), were previously shown to confer resistance to methotrexate and 5-FU, respectively, and recently a fusion cDNA of both mutant enzymes (DHFR F/S-TS G52S) was shown to confer dual resistance to both...
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