Aichi Cancer Center
Researchers describe findings in virology studies
Published in Genetics and Environmental Law Weekly, May 14th, 2005
Study 1: Immunogenic peptides in retroviral vectors may confound gene therapy.
"Retroviral vectors are the frequently applied gene delivery vehicles for clinical gene therapy, but specificity of the immunogenicity to the protein encoded by the inserted gene of interest is a problem which needs to be overcome," say researchers in Japan.
"Here, we describe human cytotoxic T-lymphocyte (CTL) clones recognizing epitopes derived from the protein encoded by the retroviral vector backbone, which were established during the course of our attempts to generate CTLs...
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