California Pacific Medical Center, San Francisco
M. avium PPE gene associated with virulence/ability to grow in macrophages
Published in Genetics and Environmental Law Weekly, May 28th, 2005
"PPE and PE gene families, which encode numerous proteins of unknown function, account for 10% of Mycobacterium tuberculosis genome.
"Mycobacterium avium genome has similar PPE and PE gene families. Using a temperature-sensitive phage phAE94 transposon mutagenesis system, a M. avium transposon library was created in the strain MAC109," researchers in the United States report.
"Screening of individual mutants in human U937 macrophages for the ability to replicate intracellularly, we identified several...
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