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University of North Carolina

Genome-wide RRV transcription profile parallels the profile for KSHV

Published in Genetics and Environmental Law Weekly, October 8th, 2005

The genome-wide transcription profile for rhesus monkey rhadinovirus closely parallels the profile for Kaposi's sarcoma-associated herpesvirus.

"Rhesus monkey rhadinovirus (RRV) and Kaposi's sarcoma-associated herpesvirus (KSHV; also called human herpesvirus 8) belong to the gamma-2 grouping of herpesviruses.

"RRV and KSHV share a high degree of sequence similarity, and their genomes are organized in a similar fashion. RRV serves as an excellent animal model system to study the gamma herpesvirus life cycle both in vitro and in vivo," scientists in the United States report.

"We have developed a high-sensitivity, high-throughput,...

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