Wistar Institute of Anatomy & Biology, Philadelphia
4.1B/Dal-1 gene does not function as tumor suppressor gene
Published in Genetics and Environmental Law Weekly, January 14th, 2006
According to recent research from the United States, "The band 4.1 proteins are cytoskeletal proteins, harboring a conserved FERM domain highly homologous to the N-terminal FERM domain of ezrin, radixin, moesin, and merlin. Recently, a truncated form of the 4.1B protein, termed Dal-1, was identified in a screen as down regulated in adenocarcinoma of the lung and was mapped to chromosome 18p11.3, which is lost in 38% of primary non-small cell lung carcinoma tumors."
"Analysis of several meningiomas has shown that Dal-1 expression was lost in 76% of the tumors. To...
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