St. Antonius Hospital, Nieuwegein
ACE2 haplotypes are associated with pulmonary disease phenotypes in sarcoidosis
Published in Genetics and Environmental Law Weekly, January 14th, 2006
"Angiotensin II (Ang II) formation by ACE or other enzymes has shown to exhibit profibrotic properties in a variety of fibrotic diseases. A homologue of ACE called ACE2 has been shown to counteract the formation of Ang II."
A. Kruit and colleagues of St. Antonius Hospital wrote, "Genetic variation in the components involved in Ang 11 formation may underlie the progression of pulmonary sarcoidosis. Seven ACE2 SNPs, located on the X-chromosome, were investigated using SSP-PCR and...
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