Fudan University, People's Republic of China
Gene modification was achieved in liver using plasmid DNA encoding Cre recombinase
Published in Genetics and Environmental Law Weekly, October 14th, 2006
According to recent research published in FEBS Letters, "The success of Cre-mediated conditional gene targeting in liver of mice has until now depended on the generation of Cre recombinase transgenic mice or on viral-mediated transduction. We sought to establish the feasibility of using hydrodynamic gene delivery of Cre recombinase into liver, using a ROSA26 EGFP mouse."
"The expression of EGFP and beta-galactosidase was exclusively detected in the liver of mice treated with hydrodynamic gene delivery of...
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