Cleft Lip
Scientists at Forsyth Institute release new data on cleft lip
Published in Genetics and Environmental Law Weekly, January 6th, 2007
New investigation results, "PVRL1 variants contribute to non-syndromic cleft lip and palate in multiple populations," are detailed in a study published in American Journal of Medical Genetics Part A. According to recent research from the United States, "Poliovirus Receptor Like-1 (PVRL1) is a member of the immunoglobulin super family that acts in the initiation and maintenance of epithelial adherens junctions and is mutated in the cleft lip and palate/ectodermal dysplasia 1 syndrome (CLPED1, OMIM #225000). In addition, a common non-sense mutation in PVRL1 was discovered more often among non-syndromic sporadic clefting cases in Northern Venezuela in a previous case-control study."
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