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Acute Lymphoblastic Leukemia

Reports from C.A. Tirado and co-researchers add new data to research in acute lymphoblastic leukemia

Published in Genetics and Environmental Law Weekly, August 4th, 2007

"We report the chromosomal findings in a 4-year-old female with precursor B-cell acute lymphoblastic leukemia (ALL). The diagnostic karyotype showed an isochromosome 7q, i(7)(q10), as well as questionable rearrangements on 9p and 11q," researchers in the United States report.

"Fluorescence in situ hybridization (FISH) studies on both interphase and metaphase cells using the MLL ''break-apart'' and the centromeric chromosome 4 probes were instrumental in the characterization of an MLL gene rearrangement, which was cryptic by conventional cytogenetic analysis. Specifically, the FISH pattern was consistent with an insertion of the 5' region of the MLL gene into chromosome...

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