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Angiotensins

Study findings from R. Singh et al provide new insights into angiotensins

Published in Genetics and Environmental Law Weekly, August 18th, 2007

"This study investigates whether angiotensin converting enzyme (ACE) inhibitors can block high glucose-induced increase of angiotensin II (Ang II) levels in cultured rat mesangial cells. Incubation of cells with high glucose for 5 days increased Ang II in the cell media (extracellular) and cell lysates (intracellular) by similar to 1.5-fold and similar to 2.2-fold, respectively," scientists in the United States report.

"Captopril blocked high glucose-induced increase in extracellular Ang II levels but not in intracellular Ang II levels. Since the inability of captopril to inhibit intracellular Ang II in intact cells could be explained by failure of the drug to enter the...

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