Gene Therapy
Babraham Institute describes research in gene therapy
Published in Genetics and Environmental Law Weekly, August 18th, 2007
Research findings, "Antisense intergenic transcription precedes Igh D-to-J recombination and is controlled by the intronic enhancer Emu," are discussed in a new report. According to a study from Cambridge, the United Kingdom, "V(D)J recombination is believed to be regulated by alterations in chromatin accessibility to the recombinase machinery, but the mechanisms responsible remain unclear. We previously proposed that antisense intergenic transcription, activated throughout the mouse Igh VH region in pro-B cells, remodels chromatin for VH-to-DJH recombination."
"Using RNA fluorescence in situ hybridization, we now show that antisense intergenic transcription occurs...
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