Gene Therapy

Boston University bioengineers devise 'dimmer switch' to regulate gene expression in mammal cells

Published in Genetics and Environmental Law Weekly, August 18th, 2007

Three Boston University biomedical engineers have created a genetic dimmer switch that can be used to turn on, shut off, or partially activate a gene’s function. Professor James Collins, Professor Charles Cantor and doctoral candidate Tara Deans invented the switch, which can be tuned to produce large or small quantities of protein, or none at all.

The research detailing their new switch, “A Tunable Genetic Switch Based on RNAi and Repressor Proteins for Regulating Gene Expression in Mammalian Cells,” appears in the July 27 issue of Cell.

This switch helps advance the field of synthetic biology, which rests on the premise that complex biological...

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Source: Genetics and Environmental Law Weekly (2007-08-18)

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