Acute Lymphoblastic Leukemia
Researchers from Children's Hospital provide details of new studies and findings in the area of acute lymphoblastic leukemia
Published in Genetics and Environmental Law Weekly, August 18th, 2007
According to recent research from the United States, "Treatment-related toxicity in acute lymphoblastic leukemia (ALL) can not only be life threatening but may also affect relapse risk. In 240 patients, we determined whether toxicities were related to 16 polymorphisms in genes linked to the pharmacodynamics of ALL chemotherapy, adjusting for age, race (self-reported or via ancestry-informative markers), sex, and disease risk group (lower- vs higher-risk therapy)."
"Toxicities (gastrointestinal, infectious, hepatic, and neurologic) were assessed in each treatment phase. During the induction phase, when drugs subject to the steroid/cytochrome P4503A pathway predominated,...
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