Amyloidosis
New amyloidosis findings from Justus-Liebig University published
Published in Genetics and Environmental Law Weekly, August 18th, 2007
Data detailed in "Genetic microheterogeneity of human transthyretin detected by IEF" have been presented. "Mutations of the human transthyretin (TTR) gene have attracted medical interest as a cause of amyloidosis. Recently, we have described in detail an electrophoretic procedure with PAGE followed by IEF in urea gradients for the study of the microheterogeneity of TTR monomers (Altland, K., Winter, P., Sauerborn, M," investigators in Giessen, Germany report.
"K., Electrophoresis 1999, 20, 1349-1364). In this paper, we present a study on 49 different mutations of TTR including 33 that result in electrically neutral amino acid substitutions. The aims of the investigation...
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