Dementia

Study data from INSERM provide new insights into dementia

Published in Genetics and Environmental Law Weekly, September 22nd, 2007

According to recent research from Lille, France, "Cerebral accumulation of P-amyloid peptide (A beta) is a central event in the pathogenesis of Alzheimer's disease (AD). Several proteases were shown to hydrolyze A beta in vitro or in cell-based assays, and are likely candidates for a role in A beta clearance in brain."

"Previous reports suggest that matrix metalloproteinases (MMPs) could be involved in such a mechanism. A functional polymorphism at position - 1171 (5A/6A) in MMP-3 was examined in two independent studies to investigate the impact of this polymorphism on the risk of developing dementia. We found that subjects APOE epsilon 4 non-carriers and 6A/6A...

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Source: Genetics and Environmental Law Weekly (2007-09-22)

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