Krabbe Disease

Findings from University of Siena, Medical Department provide new insights into Krabbe disease

Published in Genetics and Environmental Law Weekly, November 17th, 2007

"Background Inflammatory and/or immune activation occurs both in animal models (twitcher mice) and in the brain of patients with Globoid cell leukodystrophy (GLD) or Krabbe's disease (KD). In this study we evaluated in vitro the cytokine profile of KD patients and the effect of psychosine, the toxic metabolite which plays a role in the demyelination process in these patients," scientists in Siena, Italy report.

"Materials and methods We studied cytokine production by peripheral blood mononuclear cells (PBMCs) isolated from four KD patients, diagnosed on the basis of clinical criteria. Cells were cultured and stimulated with appropriate agents and the supernatants...

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Source: Genetics and Environmental Law Weekly (2007-11-17)

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