Published in Genetics and Environmental Law Weekly, December 22nd, 2007
"Mouse embryos homozygous for a targeted null mutation of the tynrd1 gene, encoding the cytosolic thioredoxin reductase, were viable at embryonic day 8.5 (E8.5) but not at E9.5. Histology revealed that txnrdl(-/-) cells were capable of proliferation and differentiation,- however, inutant embryos were smaller than wild-type littermates and failed to gastrulate. In situ marker gene analyses indicated that primitive streak mesoderm did not...
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