Life Sciences
New life sciences research from Harvard University described
Published in Genetics and Environmental Law Weekly, March 1st, 2008
Investigators publish new data in the report 'Distinct roles of chromatin-associated proteins MDC1 and 53BP1 in mammalian double-strand break repair.' According to a study from the United States, "Phosphorylated histone H2AX ('gamma-H2AX') recruits MDC1, 53BP1, and BRCA1 to chromatin near a double-strand break (DSB) and facilitates efficient repair of the break. It is unclear to what extent gamma-H2AX-associated proteins act in concert and to what extent their functions within gamma-H2AX chromatin are distinct."
"We addressed this question by comparing the mechanisms of action of MDC1 and 53BP1 in DSB repair (DSBR). We find that MDC1 functions primarily in homologous...
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