Gene Therapy
New gene therapy findings from Karolinska Institute Cancer Center, Department of Oncology described
Published in Genetics and Environmental Law Weekly, March 29th, 2008
Researchers detail in 'The oncoprotein SS18-SSX1 promotes p53 ubiquitination and degradation by enhancing HDM2 stability,' new data in gene therapy. "Mutations of the p53 gene are uncommon in synovial sarcoma, a high-grade tumor genetically characterized by the chromosomal translocation t:(X;18), which results in the fusion of SS18 with members of SSX gene family. Although implicated in tumorigenesis, the mechanisms by which SS18-SSX promotes tumor growth and cell survival are poorly defined," scientists in Stockholm, Sweden report.
"Here, we show that SS18-SSX1 negatively regulates the stability of the tumor suppressor p53 under basal conditions. Overexpression of...
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