Life Sciences

Scientists at Yale University target life sciences

Published in Genetics and Environmental Law Weekly, May 17th, 2008

New investigation results, 'Hed1 regulates Rad51-mediated recombination via a novel mechanism,' are detailed in a study published in Genes & Development. "Two RecA orthologs, Rad51 and Dmc1, mediate homologous recombination in meiotic cells. During budding yeast meiosis, Hed1 coordinates the actions of Rad51 and Dmc1 by down-regulating Rad51 activity," scientists in the United States report.

"It is thought that Hed1-dependent attenuation of Rad51 facilitates formation of crossovers that are necessary for the correct segregation of chromosomes at the first meiotic division. We purified Hed1 in order to elucidate its mechanism of action. Hed1 binds Rad51 with high...

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Source: Genetics and Environmental Law Weekly (2008-05-17)

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