Protein Therapies
New protein therapies study findings recently were reported by Y. Aubin and co-researchers
Published in Genetics and Environmental Law Weekly, May 17th, 2008
"We describe a simple, powerful, and robust NMR-based method that has the potential to greatly impact the characterization of recombinant protein therapeutics. The method ascertains the bioactive conformational identity of recombinant human granulocyte macrophage-colony stimulation factor (rhGM-CSF) produced in Streptomyces lividans versus Escherichia coli by overlaying their 2D H-1,N-15 HSQC correlation spectra," scientists in Ottawa, Canada report.
"An identical match of all resonances implies that rhGM-CSF from both processes share indistinguishable conformations that correlate with in vitro activity. The result of this method is unique among existing methods. It can...
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