Alzheimer Disease
Findings from University of Manitoba advance knowledge in Alzheimer disease
Published in Genetics and Environmental Law Weekly, May 17th, 2008
"However, the underlying mechanisms remain unclear. Here, we report that TGF-beta 1 and nuclear Smad7 and beta-catenin levels were markedly upregulated in cortical brain regions of the TgCRND8 mice, a mouse model of familial Alzheimer's disease. Coimmunoprecipitation of cortical brain tissue lysates revealed an interaction between Smad7 and beta-catenin. This interaction which was significantly enhanced in the...
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