Published in Genetics and Environmental Law Weekly, May 17th, 2008
"However, the underlying mechanisms remain unclear. Here, we report that TGF-beta 1 and nuclear Smad7 and beta-catenin levels were markedly upregulated in cortical brain regions of the TgCRND8 mice, a mouse model of familial Alzheimer's disease. Coimmunoprecipitation of cortical brain tissue lysates revealed an interaction between Smad7 and beta-catenin. This interaction which was significantly enhanced in the...
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