Alzheimer Disease
Findings from Yale University, Medical Department in Alzheimer disease reported
Published in Genetics and Environmental Law Weekly, July 26th, 2008
According to a study from the United States, "Alzheimer's disease is the most common dementia and is pathologically characterized by deposition of amyloid-beta peptide (A beta) into beta-amyloid plaques, neuronal injury and low-level, chronic activation of brain immunity(1). Transforming growth factor-beta s (TGF-beta s) are pleiotropic cytokines that have key roles in immune cell activation, inflammation and repair after injury(2)."
"We genetically interrupted TGF-beta and downstream Smad2/3 signaling (TGF-beta-Smad2/3) in innate immune cells by inducing expression of CD11c promoter-driven dominant-negative TGF-beta receptor type II in C57BL/6 mice (CD11c-DNR)(3),...
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