Crohn Disease

Study results from University of Munich in the area of Crohn disease published

Published in Genetics and Environmental Law Weekly, October 4th, 2008

According to a study from Munich, Germany, "The functional link between mutations in NOD2 and Crohn's disease (CD) has not been entirely elucidated. The 1007fs mutation results in loss of NF-kappa B activation in response to muramyl dipeptide (MDP) but has also been linked to an increased IL-1 beta processing and IL-12 release."

"We investigated the basal and MDP-triggered mRNA expression and protein release for TNF-alpha, IL-10, IL-1 beta, and IL-12p40 in peripheral blood monocytes from 40 CD patients and 15 healthy individuals with different NOD2 genotypes. Monocytes from individuals with 2 mutated NOD2 alleles (homozygous and compound-heterozygous individuals)...

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Source: Genetics and Environmental Law Weekly (2008-10-04)

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