Crohn Disease

Reports outline Crohn disease study results from H. Takedatsu et al

Published in Genetics and Environmental Law Weekly, February 14th, 2009

"Genetics studies of the serum expression of antibodies to microbial antigens may yield important clues to the pathogenesis of Crohn's disease. Our aim was to conduct a linkage study using expression of anti-CBir1, anti-I2, anti-OmpC and ASCA as quantitative traits," scientists in the United States report.

"Expression of antibodies to microbial antigens was measured by enzyme-linked immunosorbant assay (ELISA) and a standard similar to 10 cM whole genome microsatellite study was conducted. Single nucleotide polymorphism genotyping was performed using either Illumina or TaqMan MGB technology. Nuclear factor Kappa B (NF-kappa B) activation in cells from Epstein-Barr virus...

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Source: Genetics and Environmental Law Weekly (2009-02-14)

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