Angiogenesis

Studies from Hoseo University add new findings in the area of angiogenesis

Published in Genetics and Environmental Law Weekly, February 14th, 2009

According to a study from South Korea, "Integrin alpha 5 beta 1 immobilized on a ProteoChip Was used to screen new antagonistic peptides from multiple hexapeptide sub-libraries of the positional scanning synthetic peptide combinatorial library (PS-SPCL). The integrin alpha 5 beta 1-Fibronectin interaction was demonstrated on the chip."

"A novel peptide ligand, A5-1 (VILVLF), with high affinity to integrin alpha 5 beta 1 was identified from the hexapeptide libraries with this chip-based screening method on the basis of a competitive inhibition assay. A5-1 inhibits the integrin-fibronectin interaction in a dose-dependent manner (IC50; 1.56 +/- 0.28 mc M. In addition, it...

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Source: Genetics and Environmental Law Weekly (2009-02-14)

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