Neurodegenerative Disease

New findings from University of Cambridge in the area of neurodegenerative disease published

Published in Genetics and Environmental Law Weekly, March 21st, 2009

According to recent research from Cambridge, the United Kingdom, "Huntington's disease (HD) is a fatal, inherited neurodegenerative CAG disorder characterized by marked brain atrophy. We used magnetic resonance imaging (MRI) with manual volumetry, for three dimensional (3D) morphological phenotyping of ex vivo brains of R6/2 mice, the most commonly used model of HD."

"High resolution 3D images were acquired for 18 week old wild-type (WT) and R6/2 mice. Although overall brain volumes were the same between genotypes, decreases in volumes were found in the cortex and striatum of R6/2 mice, with significant volume increases in the lateral ventricles and globus pallidus....

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Source: Genetics and Environmental Law Weekly (2009-03-21)

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