Enzyme Research
New enzyme research study results reported from Kyoto University
Published in Genetics and Environmental Law Weekly, May 23rd, 2009
Investigators publish new data in the report 'Redundant roles of Srs2 helicase and replication checkpoint in survival and rDNA maintenance in Schizosaccharomyces pombe.' "Srs2 helicase is believed to function as an anti-recombinase by resolving inappropriate Rad51-DNA filament. We found synthetic lethality or poor growth of srs2 with rad3 or mrc1 in Schizosaccharomyces pombe," scientists writing in the journal Molecular Genetics and Genomics report.
"Lethality may result from a defect in non-checkpoint function of Rad3 or Mrc1 in the absence of Srs2, because srs2 rad9, srs2 chk1 cds1 or srs2 mrc1-14A (non-phosphorylatable mrc1 allele) did not show significant...
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