Adipose Tissue
Studies from Kitasato University have provided new information about adipose tissue
Published in Genetics and Environmental Law Weekly, September 12th, 2009
"Hypoxia-inducible factor (HIF) is a heterodimer composed of HIF-alpha and -beta, and to date, three HIF-alpha subunits, HIF-1 alpha, -2 alpha, and -3 alpha, have been identified. Among these HIF-alpha subunits, HIF-1 alpha represses peroxisome proliferator activator gamma 2 gene expression and then inhibits adipogenesis, and HTF-2 alpha is induced during adipose differentiation and functions as a positive regulator of adipogenesis," scientists in Tokyo, Japan report.
"We here found that like HIF-2 alpha HIF-3 alpha was induced during 3T3-L1 adipose differentiation. Reporter gene analysis revealed that HIF-2a enhanced the promoter activity, of the 5'-flanking region of...
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