Type 1 Diabetes Genetics
Researchers from Hagedorn Research Institute report recent findings in type 1 diabetes genetics
Published in Genetics and Environmental Law Weekly, January 30th, 2010
Investigators publish new data in the report 'No association of the IRS1 and PAX4 genes with type I diabetes.' According to a study from Gentofte, Denmark, "To reassess earlier suggested type I diabetes (T1D) associations of the insulin receptor substrate 1 (IRS1) and the paired domain 4 gene (PAX4) genes, the Type I Diabetes Genetics Consortium (T1DGC) evaluated single-nucleotide polymorphisms (SNPs) covering the two genomic regions. Sixteen SNPs were evaluated for IRS1 and 10 for PAX4."
"Both genes are biological candidate genes for T1D. Genotyping was performed in 2300 T1D families on both Illumina and Sequenom genotyping platforms. Data quality and concordance...
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