Acute Leukemia Genetics
New acute leukemia genetics findings from University of Chicago published
Published in Genetics and Environmental Law Weekly, April 3rd, 2010
Scientists discuss in 'Aberrant overexpression and function of the miR-17-92 cluster in MLL-rearranged acute leukemia' new findings in acute leukemia. "MicroRNA (miRNA)-17-92 cluster (miR-17-92), containing seven individual miRNAs, is frequently amplified and overexpressed in lymphomas and various solid tumors. We have found that it is also frequently amplified and the miRNAs are aberrantly overexpressed in mixed lineage leukemia (MLL)-rearranged acute leukemias," scientists in the United States report.
"Furthermore, we show that MLL fusions exhibit a much stronger direct binding to the locus of this miRNA cluster than does wild-type MLL; these changes are associated...
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