Addiction Research

Mice Lacking Brain Receptor Are Free Of Cocaine Effects

Published in Genomics and Genetics Weekly, October 5th, 2001

Mice devoid of a single brain receptor, mGluR5, appear free from the psychostimulant and the reinforcing effects of acute and repeated administration of cocaine.

The findings point toward a novel understanding of the biological processes underlying drug dependence. It has been known that following chronic administration of cocaine, the expression of mGluR5 (metabotropic glutamate receptor subtype 5) is increased in a region of the brain (the nucleus accumbens) within the brain's natural reward circuit. The currently reported study, in which the mice were rendered devoid of mGluR5 by genetic mutation, now provides compelling evidence of the functional role of this...

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Source: Genomics and Genetics Weekly (2001-10-05)

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