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Genomics and Genetics Weekly

Susan Hasty, Publisher

Table of Contents . . . May 2nd, 2003

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Genomics and Genetics Weekly | Other Publications

Fragile X/Ataxia Syndrome - Same gene found to cause both mental retardation, neurodegenerative condition

Parkinson Disease - Genetic risk factor discovered

Antibiotic Resistance - Bacteria gene transfer blamed

Gene Mapping - New technique gives scientists clearest picture yet of C. elegans genome

Hypertension Genomics and Genetics - Obesity-related hypertension affects gene expression in the heart

Stem Cell-Based Gene Therapy - Retroviral vector integration into marrow-repopulating cells can be nonrandom

Asthma and Dermatitis - Variation in Th2-specific chemokine TARC gene exists but not associated

Beta-Thalassemia - Gene therapy potential seen in gamma-globin lentiviral vector

Biochemistry - Spectrophotometric method devised to quantify linear DNA

Bladder Cancer - Link made between dietary folate, genetic instability and bladder cancer risk

Collaborations - Joint marketing, service agreement will use eTag Assay system on MegaBACE

Colon Cancer - Altered anaphase-promoting complex genes involved in colon carcinogenesis

Cystic Fibrosis - Neutral, pegylated gene lipoplexes achieve better degree of transfection

DNA Repair - Nonhomologous end joining and V(D)J recombination require an additional factor

DNA Vaccine - Progress and prospects in naked DNA gene transfer and therapy explored

Device Technology - Instrumentation company raises the bar for microarray scanning

Eating Disorders - Mutations in melanocortin 4 receptor gene linked to binge-eating behavior

Embryogenesis - Neuropeptide FF, PrRP, receptor UHR1/GPR10 genes play role during development

Heart Disease Mortality - Gene for cellular receptors could be key for lower heart risk

Heart Failure - Mechanical support induces genetic changes in failing hearts

Hereditary Spherocytosis - Endovascular splenic occlusion is an effective way to treat children

Hypertension - Researchers find genetic link to high blood pressure

Hypophosphatasia - Results released supporting use of stem cells for bone disease

Immune Response - Researchers determine fundamental mechanisms involved in immune response

Laboratory Techniques - Thermal gradient DNA chip for genotyping developed

Longevity - High levels of anti-inflammatory protein may hold clue to long life in men

Lung Cancer - Researcher shows aggregation of cancers in families of lung cancer patients

Obesity Epidemiology - High frequency of beta-2 adrenoceptor gene Gln(27)Glu polymorphism in Tongans

Obesity Genomics and Genetics - MC4R gene mutations disrupt receptors through multiple molecular mechanisms

Obesity Genomics and Genetics - More than 300 genes, markers, and regions linked to human obesity phenotypes

Obesity Therapy - Wrinkle-free mice provide clues about obesity, wrinkles and hair growth

Patents - Patent awarded for gene reassembly technology

Pharmacogenetics - Certain patients with YMDD variants of HBV may need additional therapy

Policy - Can genetic research improve public health?

Polymorphisms - Researchers describe advances in determining genetic susceptibility to disease

Research Funding - $50 million grant from Lilly endowment boosts genomics initiative

Research Funding - U.K.-Canadian consortium commits $95 million to genome research project

Stem Cell Research - Genes linked aorta-gonad-mesonephros stem cell emergence identified

Tangier Disease - Abnormal splicing of ABCA1 pre-mRNA is due to IVS2+5G>C mutation in ABCA1 gene

Therapy - Results of poll reveal what people really think about genetics

Viral Genetics - Stem-loop structures needed for expression of full-length HCV genome identified

Wiskott-Aldrich Syndrome - Retrovirally transduced HSCs improve WAS-associated T-cell signaling defects

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