Genomics and Genetics Weekly

Collaborations - HMGene enters obesity drug agreement

Collaborations - Lexicon enters neuroscience alliance for drug development

Legg-Perthes Disease - Beta fibrinogen G-455-A polymorphism is risk factor for Legg-Perthes disease

Collaborations - Medarex announces research and license agreement with Maryland company

Collaborations - Molecular cytogenetics alliance formed to validate cancer drug targets

Collaborations - Research deal to use genomic high throughput RNAi in human cells

Collaborations - Services deal signed with GE Medical Systems for ProteinChip systems China

Colorectal and Breast Cancer - Birt-Hogg-Dube in activation occurs in some renal cell, colorectal cancers

Congenital Neutropenia - One form of congenital neutropenia involves neutrophil elastase mutation

Cryptococcosis -  Cryptococcus neoformans capsule formation can be blocked by RNA interference

Cystic Fibrosis - Milestone earned for development of malabsorption treatment

Cystic Fibrosis - Orphan drug designation granted for DX-890

DNA Research - In CSR, mutation rates and patterns differ greatly, depending on the region

Leukemia - Researchers get easy access to leukemia gene information

Dermatology - Dermal-epidermal junction type VII collagen produced by fibroblasts

Dermatology - SLURP-1 is an epidermal neuromodulator; its gene is mutated in Mal de Meleda

Diabetes Genomics and Genetics - Gene linked to type 2 diabetes in population from the Netherlands

Diabetes Genomics and Genetics - Intercellular adhesion molecule-1 gene associated with type 1 diabetes

Drug Development - Hematin-targeting 9-anilinoacridines show promise as antimalarials

Drug Development - Modified GFP reporter-based assay useful for anti-TB drug screening

Drug Development - Plasmodial aspartic protease characterized

Drug Discovery - INGENOtyping agreement inked with Max-Planck Institute

Eating Disorder - Bulimia nervosa patients and normal eaters have similar 5-HTT gene mutations

Eating Disorders - Changes in the noradrenergic system underlie anorexia nervosa risk

Treacher Collins Syndrome - Novel mutation found in patient with Treacher Collins syndrome

Endocrinology - Hoxa10 transcription factor mediates endometrial differentiation

Evolutionary Biology - Chimps, humans have striking differences in genes for smell, metabolism, hearing

Familial Amyloid Polyneuropathy - Nerve degeneration in familial amyloid polyneuropathy studied

Familial Amyloid Polyneuropathy - VLDL/chylomicron plays role in amyloid formation

Fetal Diagnosis - Maternal serum reveals the presence of placental steroid sulfatase deficiency

Finance - Diagnostic technology company announces stock repurchase program

Finance - Drug discovery company announces 2003 net loss of $3,925,000

Finance - Gene identification company reports 73.7% gross profit margin

Gastroenterology -  Helicobacter pylori influences angiogenesis and gastric cancer invasion

Gene Function Discovery - Foreign rights expanded for product discovery from biodiversity

Adverse Drug Effect - Imatinib mesylate can produce immune-mediated hemolytic anemia; can be treated

Gene Suppression - Small interfering RNAs staunch genes associated with cancer growth

Gene Transfection - Novel degradable polymers offer a viable alternative to other DNA vectors

Genetic Screening - Culture, demography, and biology interact to determine genetic trait prevalence

Genomics - Genaissance enters into HAP Technology license agreement

Genomics - Human Genome Sciences announces license agreement

Genomics R&D - New genomics screening platform technology developed

Genomics Research - New business venture formed to commercialize microparticle technology

Genomics and Genetics - Cholesterol-regulated SREBP and LXR target genes identified in mice

Geriatrics - Human sirtuin 3 gene plays role in longevity

Graves Disease - Thyroid-associated ophthalmopathy can be treated by anti-inflammatories, surgery

Amyloidotic Polyneuropathy - A rapid serological assay can identify amyloidogenic transthyretin variants

HLA Typing - HLA-DRB5 allele, DRB5*0112, may be the result of intraexonic recombination

HLA Typing - South Indian Nadar have unique HLA alleles, others shared with South Asians

HLA-B Typing - A new B*38 allele, B*3809, was found in a Dutch caucasoid B-cell line

Helicobacter Pylori -  H. pylori CagA inhibits B cell p53-induced apoptosis; triggers MALT lymphoma

Hepatitis C Therapy - Consolidation therapy improves sustained response in HCV genotype 1b patients

Hepatology - Hepatitis C virus in tissue samples helps identify mixed up patient specimens

Hepatotoxicity - Collaboration signed with AstraZeneca focused on predictive toxicity

Inflammation - Nuclear factor-kappa B dependent gene expression involves p300, PARP-1

Insulin Resistance - FDA grants orphan drug designation for rhIGF-I/rhIGFBP-3, SomatoKine

Kidney Cancer - Primary renal synovial sarcoma is a spindle-cell tumor with SYT-SSX gene fusion

Anthrax - Scientists discover how anthrax creates its deadly spores

Leukemia Pathogenesis - Etoposide treatment triggers chimeric Mll gene fusions in vitro

Lipid Oxidation - Lipid oxidation products have both pro and anti-inflammatory effects

Lung Cancer - New data highlight activity of INGN 241 drug in non-small cell lung cancer

Lung Cancer - p63 Amplification, overexpression occurs early in developing lung cancer

Macular Degeneration - Company launches expansion of its R&D program in ophthalmology

Malaria - Gates Foundation gives $10 million grant to develop pregnancy malaria vaccine

Menopause - Select vitamin D receptor gene changes don't obscure bone mineral indices

Mergers and Acquisitions - Clinomics Biosciences in agreement to be acquired

Mergers and Acquisitions - Genaissance to acquire genomic-services company

Metabolic Syndrome - Potential genetic links to diabetes and cardiovascular disease discovered