Genomics and Genetics Weekly

Alcoholism - Alcoholism risk linked to gene involved in brain chemistry

Breast Cancer - HCCR-2 related to breast cancer development and p53 tumor suppressor regulation

Cancer Genetics - Longevity gene may also predict better outcome for breast cancer patients

Genetics - Genetic cancer alterations seen between ethnic populations

Sickle Cell Anemia - Spectrin ubiquitination controls spectrin complex dissociation

Acute Lymphoblastic Leukemia - Molecular analyses of ALL suggest strategies for more effective treatments

Addiction Research - Mayo Clinic receives $12 million to research addiction

Antimicrobial Drug Resistance -  Plasmodium falciparum drug resistance in India determined

Apoptosis - EGCG inhibits radiation-induced apoptosis by inactivating capase pathway

Bacteriology -  Pasteurella multocida contains multiple hemoglobin-binding proteins

Breast Cancer - Lymphatic mapping suggested when invasive breast cancer is suspected

Breast Cancer - Malignant breast cancer cells revert to normal with manipulation

Business Update - MIT's Deshpande strikes first funding and licensing deals

Cancer Diagnostics - Validated cancer SNP assays launched using MGB Eclipse Probe Systems

Cancer Prognosis - Predicting cancer patient survival with gene-expression data

Cancer Therapy - Genetic analyses of angiogenic growth factors generate treatment alternatives

Cancer Therapy - Microwaves regress colorectal tumor tissue in mice

Cancer Therapy - Research shows evidence of synergy and molecular activity of MG98

Cancer Therapy - Therapy combining cisplatin and overexpressed CAD promotes tumor destruction

Cardiology - FDA approves VITALITY2 implantable defibrillator

Cardiology - Study: Gene-based cardiovascular therapies will create new treatment options

Cardiovascular Disease - Genaissance inks agreements for cardiac tests

Chemotherapy - gONC increases conformational stability and toxicity for cancer cells

Collaborations - Agreement signed for HIV molecular diagnostics

Collaborations - Distribution into Latin America expanded to market SmartCycler

Collaborations - Genes To Leads drug discovery contract signed with Novartis

Coxsackie B Virus - RNA recombination plays induces genomic change in coxsackie B viruses

Crohn Disease - Gene discovered that predisposes people to gastrointestinal disorder

Diabetes Genomics and Genetics - Repression of HNF-1beta linked to maturity-onset diabetes of the young

Diabetes Pathogenesis - Acetylation of BETA2 important in insulin gene expression

Diagnostics - Early FAMM diagnosis and prophylaxis decreases neoplastic transformation risk

Diagnostics - New RNA profiles of cell-free saliva can diagnose human disease

Drug Development - 6-Nitro-7-hdroxycoumarin novel therapeutic agent for renal cell carcinoma

Endocrinology - Spontaneous and iatrogenic ovarian hyperstimulation syndrome show differences

Endocrinology - Thyroglobulin polymorphic variation increases non-medullary thyroid cancer risk

Enzymology - Genetic diversity causes COX-1 to compensate when COX-2 is suppressed

Epidemiology - Multilocus sequence Staphylococcus epidermidis typing effective

Epilepsy - Study confirms basis of epilepsy diagnostic test

Epstein-Barr Virus - Epitope from Epstein-Barr virus protein elicits sustained immune response

Evolutionary Biology - Biologist's find alters the bacteria family tree

Finance - Ophthalmic company reports 2003 net loss of $7 million

Food-Borne Disease - Real-time PCR assay effective for Listeria detection in food samples

Gastric Cancer - BMP-2 modulates proliferation and differentiation of gastric cancer cells

Gene Linkage - Specific chromosomes may be linked to the age at which menopause commences

Gene Transfer - A water-soluble and nonionic polyphosphoester fosters naked-DNA gene therapy

Genetic Research - Genetically modified mouse celebrates significant age

Genetic Research - Zoo monkey undergoes double cataract surgery in Buffalo

Genetic Risk Factor - Age-related macular degeneration may have gene-linked origins

Genomics - Cerebral infarction susceptibility with TNF-alpha gene polymorphism

Genomics - Cyclin-dependent kinase inhibitor p21 induces Flt3-ITD leukemogenesis

Genomics - Genomic-services company reports record revenue and net income for 2003

Genomics - Human Genome Sciences receives milestone payment from initiation of trials

Genomics - Notch1 gene involved in ATRA-modulated differentiation process in APL

Genomics - P73 A4T14 genotype associated with cervical cancer risk

Genomics - Ptc acts as a tumor suppressor gene in bladder cancer

Geriatrics - World's oldest mouse reaches milestone birthday

Glioblastoma - ING4 tumor suppressor protein modulates angiogenesis and brain tumor activity

Gynecology - Women with uterine fibroids may lack CCN5 gene functionality

HIV Research - Clues discovered to Trojan horse gene in HIV infection

HIV Therapy - Board recommends dosing of final two patients in VRX496 trial

HIV/AIDS - Study evaluating Resurgex in immunocompromised patients completed

HIV/AIDS Enzymology - E152 amino acid region of HIV integrase characterized

HIV/AIDS Gene Therapy - Recombinant AAV-2 useful as anti-HIV RNAi vector

HIV/AIDS Opportunistic Infection -  Pneumocystis carinii p55 variants identified

HIV/AIDS Opportunistic Infection - Essential eukaryotic core identified from P. carinii

HIV/AIDS Proteomics - HIV Tat binds directly to NFkappaB enhancer

Hematology - Eurya emarginata extracts inhibit leukemia cell growth via apoptosis induction

Hematology - Heparin reverses preeclampsia in a factor V Leiden mutation carrier

Human Microarray - New CodeLink human whole genome bioarray launched

Hypercholesterolemia - INEGY approved in Germany for treatment of elevated cholesterol