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AIDS/HIV Genomics and Genetics

Wild-type CCR5 confers HIV-1 cross-clade resistance

Published in Genomics and Genetics Weekly, May 21st, 2004

Scientists describe risk associated HIV-1 cross-clade resistance of whole peripheral blood mononuclear cells from exposed uninfected individuals with wild-type CCR5.

According to a study from the United States, "Highly HIV exposed, persistently uninfected individuals (EUs) may hold clues to the generation of effective vaccine induced acquired immunity against HIV, and considerable effort has been devoted to detecting and characterizing HIV specific immune responses in EU cohorts. When searching for such clues, it is important to exclude individuals with genetically determined absence of receptors, as this protective mechanism could not be induced by HIV-specific...

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